I know it's not impacting everyone, but for me, going from 12.7.1 to 12.8.1 introduced a new crash which happens every time I try to quit the app: it just shows the generic 'Send to Avid' crash reporter. Apparently, the same happened for some others who tried 12.8.0 also.
For me, it's completely tied to whether or not I have Guitar Rig 5.2.2 in my plugins folder or not, but there could well be other plugins related to this as well.
Yes, I get that it's also an issue with the plugin itself (and I've contacted Native Instruments on this as well), but something obviously changed between 12.7.1 (my last version) and 12.8.1 which made it less stable when handling this plugin, as it was never an issue before. It makes sense to make PT more resilient where possible.
FYI, I am currently on macOS 10.12.6.